Trimi vs Fifty 410
$125/mo against $133/mo for tirzepatide. Which is worth it, and for whom.
Updated 2026-09-18 · every price checked by hand
How we make money: one company on this page — Coreage Rx — pays us a commission when a reader signs up through our link. It buys them nothing else: not a better score, not a higher place in the table, not the removal of a single criticism. Our scoring method and full disclosure are both public.
Both sell tirzepatide. Trimi costs $125 a month and Fifty 410 costs $133, a difference of $8 a month or about $96 a year. Over a year that is the whole question.
Trimi is lowest flat price with named pharmacies. Fifty 410 is prepaid blocks with no subscription. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though for a cash payer it usually is.
Side by side
| Trimi | Fifty 410 | |
|---|---|---|
| Advertised from | $125 | $133 |
| Membership on top | None | None |
| True monthly cost | $125 | $133 |
| Roughly, per year | $1,500 | $1,596 |
| Price includes medication | Yes | Yes |
| Names its pharmacy | Yes | Not published |
| Our score | 4.6 / 5 | 4.2 / 5 |
Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.
Where Trimi wins
- The cheapest verified flat rate for compounded tirzepatide in this comparison.
- Names its pharmacies with a licence number and offers a certificate of analysis — almost nobody else in this market does.
- Price does not move as your dose is adjusted.
- No membership fee stacked on the medication price.
Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months.
Where Fifty 410 wins
- Genuinely no subscription — you buy a block and nothing recurs.
- Among the lowest tirzepatide rates verified.
- Unusually detailed public explanation of 503A standards and batch testing.
- No payment taken until a provider approves you.
The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.
How they score
| What we weigh | Weight | Trimi | Fifty 410 |
|---|---|---|---|
| True monthly cost | 30% | 5 | 4.8 |
| Price honesty | 20% | 4.8 | 4.6 |
| Clinical support | 20% | 4 | 3.5 |
| Pharmacy sourcing | 15% | 4.8 | 4.2 |
| Cancelling | 15% | 4.2 | 3.3 |
Trimi scores higher overall at 4.6 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.
Which should you pick?
- Pick Trimi if cost is the binding constraint. Over a year the gap is about $96, which is real money for the same class of medication.
- Pick Fifty 410 if what it does better matters to you — genuinely no subscription — you buy a block and nothing recurs.
- If sourcing matters, note that Trimi publishes which pharmacy compounds its medication and Fifty 410 does not.
The verdict
On the yearly arithmetic, Trimi at $125 a month is the more defensible choice on arithmetic alone. Fifty 410 earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Trimi and Fifty 410.
How they sit against everyone else
| Programme | Per month | Per year | Extra vs cheapest |
|---|---|---|---|
| Coreage Rx Cheapest no membership fee | $199 | $2,388 | +$888 |
| Trimi no membership fee | $125 | $1,500 | — |
| Ozari Health no membership fee | $125 | $1,500 | — |
| Fifty 410 no membership fee | $133 | $1,596 | +$96 |
| PlexusDx no membership fee | $189 | $2,268 | +$768 |
| Ivím Health no membership fee | $199 | $2,388 | +$888 |
| Zealthy no membership fee | $216 | $2,592 | +$1,092 |
| Hims & Hers incl. $39 monthly fee | $238 | $2,856 | +$1,356 |
| Coby Health no membership fee | $239 | $2,868 | +$1,368 |
| Mochi Health incl. $79 monthly fee | $278 | $3,336 | +$1,836 |
| Eden incl. $99 monthly fee | $298 | $3,576 | +$2,076 |
| Lemonaid Health incl. $49 monthly fee | $348 | $4,176 | +$2,676 |