Fifty 410 vs PlexusDx
$133/mo against $189/mo for tirzepatide. Which is worth it, and for whom.
Updated 2026-09-18 · every price checked by hand
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Both sell tirzepatide. Fifty 410 costs $133 a month and PlexusDx costs $189, a difference of $56 a month or about $672 a year. Over a year that is the whole question.
Fifty 410 is prepaid blocks with no subscription. PlexusDx is pharmacy transparency and genetic testing. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though for a cash payer it usually is.
The yearly view. Over twelve months that gap is $672. On a treatment most people stay on for years rather than months, that compounds: five years at this difference is $3,360. That is the number worth deciding on, not the monthly one.
Side by side
| Fifty 410 | PlexusDx | |
|---|---|---|
| Advertised from | $133 | $129 |
| Membership on top | None | None |
| True monthly cost | $133 | $189 |
| Roughly, per year | $1,596 | $2,268 |
| Price includes medication | Yes | Yes |
| Names its pharmacy | Not published | Yes |
| Our score | 4.2 / 5 | 4.4 / 5 |
Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.
Where the money actually goes
They differ on 4 of the 7 things we track, and behave the same on the other 3. The differences are what the price gap is actually buying.
| Fifty 410 | PlexusDx | |
|---|---|---|
| Price is the same at every dose | No | Yes |
| Month-to-month without prepaying a block | No | Yes |
| Names the compounding pharmacy publicly | No | Yes |
| Offers an oral or sublingual option | No | Yes |
What each one charges for: Fifty 410
- Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
- High-dose tirzepatide protocol at $183/month, sold as a $549 three-month block.
- No membership, no subscription and no recurring charges — you buy a block outright.
- Provider consultation and free 1-2 day shipping included in the price.
- States it is a telehealth platform that does not compound or distribute medication itself, and that preparations come from FDA-registered 503A pharmacies.
- Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.
- No payment taken unless a provider approves you.
Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.
What each one charges for: PlexusDx
- GLP-1 weight-loss programmes start at $129/month.
- Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
- A $189/month microdose tier is offered for compounded semaglutide or tirzepatide.
- No membership or platform fee is charged alongside the medication.
- Publicly names six 503A pharmacy partners: Belmar, Strive, Epiq Scripts, Casa Pharma Rx, The Pharmacy Hub and Foothills.
- Clinical oversight via LionMD, with named physicians and NPI numbers published.
- Licensed providers in all 50 states; CLIA-certified labs for its testing line.
Where it wins: The most detailed pharmacy disclosure in this comparison — six named 503A partners. Watch for: The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.
What each does well
Fifty 410.
- Genuinely no subscription — you buy a block and nothing recurs.
- Among the lowest tirzepatide rates verified.
PlexusDx.
- The most detailed pharmacy disclosure in this comparison — six named 503A partners.
- Names its prescribing physicians along with their NPI numbers.
How they score
| What we weigh | Weight | Fifty 410 | PlexusDx |
|---|---|---|---|
| True monthly cost | 30% | 4.8 | 4.6 |
| Price honesty | 20% | 4.6 | 4.5 |
| Clinical support | 20% | 3.5 | 3.8 |
| Pharmacy sourcing | 15% | 4.2 | 4.9 |
| Cancelling | 15% | 3.3 | 4 |
PlexusDx scores higher overall at 4.4 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.
Which saves you more
- Pick Fifty 410 if cost is the binding constraint. Over a year the gap is about $672, which is real money for the same class of medication.
- Pick PlexusDx if what it does better matters to you — the most detailed pharmacy disclosure in this comparison — six named 503a partners.
- If sourcing matters, note that PlexusDx publishes which pharmacy compounds its medication and Fifty 410 does not.
The verdict
On the yearly arithmetic, Fifty 410 at $133 a month is the more defensible choice on arithmetic alone. PlexusDx earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Fifty 410 and PlexusDx.
How they sit against everyone else
| Programme | Per month | Per year | Extra vs cheapest |
|---|---|---|---|
| Coreage Rx Cheapest no membership fee | $199 | $2,388 | +$888 |
| Trimi no membership fee | $125 | $1,500 | — |
| Ozari Health no membership fee | $125 | $1,500 | — |
| Fifty 410 no membership fee | $133 | $1,596 | +$96 |
| PlexusDx no membership fee | $189 | $2,268 | +$768 |
| Ivím Health no membership fee | $199 | $2,388 | +$888 |
| Zealthy no membership fee | $216 | $2,592 | +$1,092 |
| Hims & Hers incl. $39 monthly fee | $238 | $2,856 | +$1,356 |
| Coby Health no membership fee | $239 | $2,868 | +$1,368 |
| Mochi Health incl. $79 monthly fee | $278 | $3,336 | +$1,836 |
| Eden incl. $99 monthly fee | $298 | $3,576 | +$2,076 |
| Lemonaid Health incl. $49 monthly fee | $348 | $4,176 | +$2,676 |