Fifty 410 vs Hims & Hers

Both sell tirzepatide. Fifty 410 costs $133 a month and Hims & Hers costs $238, a difference of $105 a month or about $1,260 a year. Over a year that is the whole question.

Fifty 410 is prepaid blocks with no subscription. Hims & Hers is widest range of formats. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though for a cash payer it usually is.

Side by side

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

Where the money actually goes

They differ on 3 of the 7 things we track, and behave the same on the other 4. The differences are what the price gap is actually buying.

What each one charges for: Fifty 410

• Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
• High-dose tirzepatide protocol at $183/month, sold as a $549 three-month block.
• No membership, no subscription and no recurring charges — you buy a block outright.
• Provider consultation and free 1-2 day shipping included in the price.
• States it is a telehealth platform that does not compound or distribute medication itself, and that preparations come from FDA-registered 503A pharmacies.
• Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.
• No payment taken unless a provider approves you.

Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.

What each one charges for: Hims & Hers

• Weight-loss membership advertised at $39 for the first month.
• Compounded GLP-1 injections priced from $199/month.
• Oral medication kits priced from $79/month.
• Branded Zepbound offered at $1,899/month.
• Company has announced oral semaglutide pricing starting around $49/month, with the 1.5 mg dose around $149/month.

Where it wins: One account covers oral, compounded injectable and branded options. Watch for: The advertised entry prices and the membership are separate charges. Add $39/month to whatever medication figure you were quoted.

What each does well

Fifty 410.

• Genuinely no subscription — you buy a block and nothing recurs.
• Among the lowest tirzepatide rates verified.

Hims & Hers.

• One account covers oral, compounded injectable and branded options.
• Large enough to keep supply steady when smaller sellers run dry.

How they score

Fifty 410 scores higher overall at 4.2 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

Which saves you more

• Pick Fifty 410 if cost is the binding constraint. Over a year the gap is about $1,260, which is real money for the same class of medication.
• Pick Hims & Hers if what it does better matters to you — one account covers oral, compounded injectable and branded options.
• Ask both which pharmacy compounds the medication and whether it is a 503A or 503B facility. Neither publishes it.

The verdict

On the yearly arithmetic, Fifty 410 at $133 a month is the more defensible choice on arithmetic alone. Hims & Hers earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Fifty 410 and Hims & Hers.

How they sit against everyone else