Zepbound alternatives

Zepbound is Eli Lilly’s brand of tirzepatide, approved for weight management. Self-pay pricing has been listed around $299 to $499 a month, which is what sends most people looking for alternatives.

The realistic alternatives fall into two groups: compounded tirzepatide, which is the same molecule prepared by a pharmacy and not FDA-approved, and a different drug entirely such as semaglutide or one of the new approved pills. This page covers the first group, priced honestly.

What gets a programme onto this table

• Delivers tirzepatide — the same active ingredient as Zepbound.
• Monthly price includes the medication.
• Sorted cheapest first on the billed figure.

20 of the 23 providers we track qualify. Every figure checked by hand and verified 2026-09-18 and re-checked periodically.

The list

Every row below is priced against Zepbound at $499 a month, and sorted by how much it saves you over a year. We use the $499 self-pay figure listed for the 5 mg, 7.5 mg and 10 mg single-dose vials; lower starting doses have been listed nearer $299. Ranked on our overall score rather than price alone — the cheapest option is on the cheapest tirzepatide page.

Cheapest qualifying option: Trimi at $125 a month. Our featured partner is pinned to the top of the list where it qualifies — see how we rate for who scores higher.

1. Coreage Rx — Best overall on true monthly cost

$199 a month, no membership fee. Flat-rate telehealth program for compounded GLP-1s. The medication, the clinician visits and the ongoing check-ins are quoted as one number, with no separate membership billed alongside it.

The $79 semaglutide and $129 tirzepatide rates require 12-month plans. One-month plans are $139 and $199 respectively. Read the payment and refund terms before committing to a longer plan. Read the full Coreage Rx review.

2. SuperHealthy Rx — Public offer; not independently scored

$135 a month, no membership fee. Online provider review for compounded semaglutide and tirzepatide; provider visit and shipping included according to the offer.

Confirm the total upfront payment, renewal, state availability and dispensing pharmacy. Read the full SuperHealthy Rx review.

3. Likeness Rx — Public offer; not independently scored

$199 a month, no membership fee. Likeness Rx offers online access to compounded semaglutide and tirzepatide. Its public page lists semaglutide from $79/month; tirzepatide from $129/month.

The lowest monthly equivalents accompany 12-month subscriptions: $948 for semaglutide or $1,548 for tirzepatide. One-month plans are $139 and $199. The page says the selected term renews automatically; check the amount due and cancellation date. Read the full Likeness Rx review.

4. Trimi — Lowest flat price with named pharmacies

$125 a month, no membership fee. Flat-rate compounded GLP-1 programme on annual plans, with medical oversight through the Arora Health clinician network and publicly named 503A compounding pharmacies.

Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months. Read the full Trimi review.

Two things worth knowing before you buy on price

Before you spend anything: approved oral GLP-1s start at $149 a month and Medicare drops to $50 in July 2026. Both undercut a large part of this market, and neither is compounded.

In SURMOUNT-1, adults with obesity lost an average of 19.5% of body weight on 10 mg and 20.9% on 15 mg over 72 weeks. That figure comes from a controlled trial of the active ingredient, not from any particular seller's product.