PlexusDx semaglutide review
$2,268 a year, all in. That is $1,248 more than the cheapest option. Pharmacy transparency and genetic testing.
Updated 2026-09-18 · every price checked by hand
About $2,268 a year for compounded semaglutide at $189 a month, no membership, same price at every dose.
More than the $99 leaders and less than every membership-charging programme in the table. What the difference buys is verifiability — six named pharmacies and named prescribers, published rather than implied.
The yearly bill
| PlexusDx · semaglutide | |
|---|---|
| Advertised from | $129/mo |
| Membership on top | None |
| What you actually pay | $189/mo |
| Over twelve months | $2,268 |
| Versus the cheapest option | +$1,248 a year |
| Cheapest-first position | 9 of 16 |
No membership fee, and the price does not change as the dose is adjusted.
Where the money goes
No fee behind the medication price and no dose surcharge. A $189 microdose tier also exists, which is a different treatment from full-dose therapy and should not be compared with it on cost.
Prescription GLP-1 and peptide programmes with no membership fee, built around genetic testing, using independent clinicians and a publicly listed set of 503A pharmacies.
What the same money buys elsewhere
Coreage Rx semaglutide is $948 on a twelve-month plan, Trimi is about $1,188 and Zealthy roughly $1,812 at the recorded rates. PlexusDx’s pharmacy disclosures should be considered separately from price.
| Programme | Per month | Per year | Extra vs cheapest |
|---|---|---|---|
| Coreage Rx Cheapest no membership fee | $139 | $1,668 | +$648 |
| SuperHealthy Rx no membership fee | $85 | $1,020 | — |
| Likeness Rx no membership fee | $139 | $1,668 | +$648 |
| Ozari Health no membership fee | $86 | $1,032 | +$12 |
| Trimi no membership fee | $99 | $1,188 | +$168 |
| Zealthy no membership fee | $151 | $1,812 | +$792 |
Is the extra worth it?
About $1,080 a year more than the floor. Worth it if the compounding question is what has been holding you back; not if you have already made peace with it.
What we checked
- GLP-1 weight-loss programmes start at $129/month.
- Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
- A $189/month microdose tier is offered for compounded semaglutide or tirzepatide.
- No membership or platform fee is charged alongside the medication.
- Publicly names six 503A pharmacy partners: Belmar, Strive, Epiq Scripts, Casa Pharma Rx, The Pharmacy Hub and Foothills.
- Clinical oversight via LionMD, with named physicians and NPI numbers published.
- Licensed providers in all 50 states; CLIA-certified labs for its testing line.
Verified 2026-09-18. Prices in this market move, so treat anything older than a month as a starting point rather than a quote.
The good
- The most detailed pharmacy disclosure in this comparison — six named 503A partners.
- Names its prescribing physicians along with their NPI numbers.
- No membership fee, and flat pricing across the dose range.
- Genetic and blood testing available alongside the prescription.
The bad
- The genetics-led positioning adds cost and complexity some people will not want.
- The $129 figure is a programme floor rather than the injection price.
- Weight care sits alongside a broad longevity and supplement line rather than being the sole focus.
Watch for this at checkout. The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.
Verdict
Buy this one for the disclosure, not the price. On that measure nothing else here comes close.
Full workings for every programme are in the cheapest semaglutide programmes, and our scoring is explained on how we rate.
Read next
Coreage Rx pays us a commission on sign-ups through our links. It does not affect our scores or rankings. How we rate · Disclosure