Review

PlexusDx semaglutide review

$2,268 a year, all in. That is $1,248 more than the cheapest option. Pharmacy transparency and genetic testing.

Illustration of bottles and boxes lined up on a shelf

Recorded article date: 2026-09-18

This article retains historical comparison material. Its record date is not a current offer check. Selected newer reviews have their own dates and limits; consult those reviews and the applicable written terms before comparing a purchase.

About $2,268 a year for compounded semaglutide at $189 a month, no membership, same price at every dose.

More than the $99 leaders and less than every membership-charging programme in the table. What the difference buys is verifiability — six named pharmacies and named prescribers, published rather than implied.

The yearly bill

Historical comparison: saved figures with their record dates. Monthly figures may be equivalents; multiplying by twelve models an unchanged input, not a confirmed annual bill. Publisher-selected placement differs from numerical order.
PlexusDx · semaglutide
Advertised from$129/mo
Membership on topNone
What you actually pay$189/mo
Over twelve months$2,268
Versus the cheapest option+$1,248 a year
Cheapest-first position9 of 16

No membership fee, and the price does not change as the dose is adjusted.

Where the money goes

No fee behind the medication price and no dose surcharge. A $189 microdose tier also exists, which is a different treatment from full-dose therapy and should not be compared with it on cost.

Prescription GLP-1 and peptide programmes with no membership fee, built around genetic testing, using independent clinicians and a publicly listed set of 503A pharmacies.

What the same money buys elsewhere

Coreage Rx semaglutide is $948 on a twelve-month plan, Trimi is about $1,188 and Zealthy roughly $1,812 at the recorded rates. PlexusDx’s pharmacy disclosures should be considered separately from price.

Historical comparison: saved figures with their record dates. Monthly figures may be equivalents; multiplying by twelve models an unchanged input, not a confirmed annual bill. Publisher-selected placement differs from numerical order.
ProgrammeRecorded monthly figureRecorded figure × 12Difference from stored minimum × 12Record date
Coreage Rx Paid first placement
Recorded membership: $0		$139$1,668+$6482026-10-04
SuperHealthy Rx Publisher-selected placement
Recorded membership: $0		$85$1,020—2026-10-04
Likeness Rx Publisher-selected placement
Recorded membership: $0		$139$1,668+$6482026-10-04
Ozari Health
Recorded membership: $0		$86$1,032+$122026-09-18
Trimi
Recorded membership: $0		$99$1,188+$1682026-09-18
Zealthy
Recorded membership: $0		$151$1,812+$7922026-09-18

Is the extra worth it?

About $1,080 a year more than the floor. Worth it if the compounding question is what has been holding you back; not if you have already made peace with it.

What we checked

  • GLP-1 weight-loss programmes start at $129/month.
  • Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
  • A $189/month microdose tier is offered for compounded semaglutide or tirzepatide.
  • No membership or platform fee is charged alongside the medication.
  • Publicly names six 503A pharmacy partners: Belmar, Strive, Epiq Scripts, Casa Pharma Rx, The Pharmacy Hub and Foothills.
  • Clinical oversight via LionMD, with named physicians and NPI numbers published.
  • Licensed providers in all 50 states; CLIA-certified labs for its testing line.

Verified 2026-09-18. Prices in this market move, so treat anything older than a month as a starting point rather than a quote.

The good

  • The most detailed pharmacy disclosure in this comparison — six named 503A partners.
  • Names its prescribing physicians along with their NPI numbers.
  • No membership fee, and flat pricing across the dose range.
  • Genetic and blood testing available alongside the prescription.

The bad

  • The genetics-led positioning adds cost and complexity some people will not want.
  • The $129 figure is a programme floor rather than the injection price.
  • Weight care sits alongside a broad longevity and supplement line rather than being the sole focus.

Watch for this at checkout. The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.

Verdict

Buy this one for the disclosure, not the price. On that measure nothing else here comes close.

Full workings for every programme are in the cheapest semaglutide programmes, and our scoring is explained on how we rate.

Read next

Coreage Rx semaglutide review$1,668 a year, all in. That is $648 more than the cheapest option. Best overall on true monthly cost.Likeness Rx semaglutide review$1,668 a year, all in. That is $648 more than the cheapest option. Public offer; not independently scored.Ozari Health semaglutide reviewHow to read a semaglutide offer, plan a first payment and examine cancellation terms before comparing commitments.Comparing semaglutide costs over a yearA calendar-based budgeting guide with historical figures, worked hypothetical payments and explicit renewal assumptions.How to cut your GLP-1 billSeven checks that routinely save $1,000 or more a year on exactly the same prescription.

CoreAge Rx pays us a commission on sign-ups through our links and pays for the first position in our price tables where included. How we rate · Disclosure